Lecture Series

Language English
From 2010/03/09 15:00
To 2010/03/09 17:00
PlaceRoom 110, Building No.3, Faculty of Science, Kyoto University
Title GCOE集中講義 (2) "Discrete models of protein geometry"　
Field Other
SpeakersRobert Penner 氏
AffiliationAarhus Univ./Univ. of Southern California
Abstract1) "Proteins and their intrinsic geometry"

　　This first lecture will introduce proteins in several guises: poetical, chemical, geometrical, dynamical and empirical.

2) "Discrete models of protein geometry"

　　Techniques from decorated Teichmller theory provide natural discrete models of protein geometry by associating fatgraphs with discrete labels to proteins. Attributes of the associated fatgraph may be taken as protein descriptors, but these attributes must be robust for experimental errors and/or indeterminacies in order to be meaningful. A number of robust such descriptors have been successfully applied to give new methods of protein domain classification.

3) "Protein moduli space"

　　The discrete model leads naturally to a continuous model of proteins, in effect, amounting to the passage from G=Z/2 to G=SO(3) graph connections. This, in turn, leads to a sensible definition of the moduli space of proteins. This furthermore uncovers a treasure trove of new structure that can be derived from the standard empirical databases and applied to the prediction of protein folding.